Seth Johnson and Paul Peschisolido are two of five first-team players set to leave Derby before the start of the side′s Premiership campaign.
Danish winger Morten Bisgaard, defender Paul Boertien and goalkeeper Lee Grant are also being released by the side who won the Championship play-offs final.
Johnson, 28, made 146 appearances for Derby over two spells - with a £7m move to Leeds coming in between the periods.
Peschisolido, 36, arrived at Pride Park in March 2004 from Sheffield United.
Young players Steven Cann, Lionel Ainsworth and Tom Cumberworth will also be leaving the club.
30 04 2007
Derby County have recalled teenage forward Lionel Ainsworth from his loan spell at Wycombe Wanderers.
The 19-year-old has been with the League Two side since February and has made three starts, with a further four appearances as a substitute.
But he has not featured since the start of April.
Earlier this season he has also been at loan at League One outfit Bournemouth and in the Conference National side with Halifax Town.
22 02 2007
Wycombe Wanderers have signed Derby forward Lionel Ainsworth on loan for the rest of the season.
It is the third loan move of the season for the 19-year-old, who has already had temporary spells with Bournemouth and Halifax this season.
He spent the first half of the campaign with the Cherries but made just nine appearances, while he had two further outings in his month at The Shay.
Ainsworth made his Rams debut last season but has not featured this term.
He will be eligible to play in the League Two play-offs if Wycombe are involved.